Endocrine Abstracts

Introduction: Salivary testosterone (Sal-T) reflects the plasma free testosterone fraction that can flow passively through the salivary glands and appears to be a strong correlation with the Calculated free testosterone (CFT) in both eugonadal and hypogonadal men. Since the collection of saliva is simple, noninvasive and inexpensive, the Sal-T is a promising tool for the screening of hypogonadism. Despite the initial interest that Sal-T has aroused, new clinical studies are ne...

Introduction: Free testosterone (FT) and bioavailable testosterone (BT), are better surrogate markers of the androgenic status of the individual than total testosterone (TT). Calculated FT (CFT) and calculated BT (CBT) which take into consideration the kinetics of the bond between FT and albumin and SHBG, provide results practically identical to those of the reference techniques. Salivary testosterone (Sal-T) is a promising tool in the study of gonadal pathology. The interassa...

Context: The determination of human chorionic gonadotropin (hCG) in cerebrospinal fluid (CSF) is useful for the differential diagnosis of suprasellar lesions. However, the concentrations that prove diagnostic for neurohypophyseal germinoma have not been well defined. In addition, the immunoassays used for such determination are the same as those applied in serum, and few studies have been performed regarding the validation of such techniques in CSF.Objec...

Introduction: This study aimed to determine the timeframe to achieve hormonal normalization considering dosing patterns of Somatuline Autogel (SOM, lanreotide) used in clinical practice.Methods: From March 2013 to October 2013 clinical data from 62 patients with active acromegaly treated with SOM for &gE;4 months who achieved hormonal control (GH levels <2.5 ng/ml and/or normalised IGF1 on &gE;two evaluations) at 17 Spanish hospitals were collected i...